Enthesopathy can occur at the shoulder, elbow, wrist, carpus, hip, knee, ankle, tarsus, or heel bone, among other regions.

Enthesopathies may take the form of spondyloarthropathies (joint diseases of the spine) such as ankylosing spondylitis, or psoriatic arthritis, plantar fasciitis, and Achilles tendinitis.

[citation needed] The natural history of the two most common enthesopathies (plantar fasciitis and lateral epicondylitis-both mislabeled as inflammatory) is resolution over a period of about one year without treatment.

Injection of corticosteroid, platelet-rich plasma, stem cells, and extracorporeal shockwave therapy are examples of treatments that are not supported by experimental evidence and remain open to debate.

The concept that a calcified attachment can be removed surgically is highly debatable as these calcifications are a regular part of an enthesopathy.