[6] Entering organized team activities, Murray was expected to compete for a job as the starting cornerback against Steven Nelson, Marcus Cooper, Phillip Gaines, KeiVarae Russell, and D. J.

[8] Throughout training camp, he competed for the job at safety against Jamell Fleming, Stevie Brown, Daniel Sorensen, Ron Parker, Akeem Davis, and Shakiel Randolph.

[9][10] Head coach Andy Reid named Murray the backup free safety behind Ron Parker to start the regular season.

[11] He made his professional regular season debut in the Kansas City Chiefs season-opener against the San Diego Chargers and recorded his first career tackle during a 33–27 overtime victory.

[14] The Chiefs finished first in the American Football Conference (AFC) West with a 12–4 record, clinching a first round bye and home field advantage.

[12] During organized team activities and training camp, Murray competed for a job as a backup safety against Daniel Sorensen, Leon McQuay III, Marqueston Huff, and Jordan Stern.

[16] Starting strong safety Eric Berry tore his Achilles tendon in the Chiefs' season-opening 42–27 victory at the New England Patriots and was expected to miss the rest of the season.

[18] On December 31, 2017, he earned his second career start after the Chiefs clinched a playoff berth and head coach Andy Reid opted to rest Daniel Sorensen and Ron Parker.