He has also been a member of the New York Giants, New Orleans Saints, Chicago Bears, Jacksonville Jaguars and Tennessee Titans.

Edwards attended Prosper High School for his freshman and sophomore year, where he was a three-sport athlete in football, basketball and track.

[1] Edwards recorded 69 tackles and three sacks as a freshman on top of catching 17 passes for 361 yards and three touchdowns.

[2] As a senior in 2011, he recorded 72 tackles and 11 sacks and was the USA Today High School Defensive Player of the Year.

In track & field, Edwards competed as a shot putter during his final two years at Denton, recording a top-throw of 15.08 meters (49 ft, 3 in) at the 2012 Richardson Invitational, where he placed first.

According to ESPN recruiting analyst Craig Haubert, Edwards was similar to Da'Quan Bowers at the same stage of their careers.

[7][8] In his true freshman year in Tallahassee, Edwards was initially projected to redshirt, but then forced into action due to the loss of Brandon Jenkins in week one.

On January 15, 2021, Edwards was suspended by the NFL for the first two games of the 2021 season for violating the league's performance-enhancing drugs policy.

While the elder Edwards played college football at Florida State, the younger stayed in Mississippi with his grandmother, Ruth Chambers, and Mario Sr.'s sister and two brothers.