Espy is a census-designated place (CDP) in Columbia County, Pennsylvania, United States.

[6] It is in the southwestern corner of Scott Township and is bordered by U.S. Route 11 to the north, the Susquehanna River to the south, Almedia to the east, and Bloomsburg, the county seat, to the west and northwest.

[7] Espy is one of several small CDPs on the north side of the Susquehanna River between Bloomsburg and Berwick.

As of the census[9] of 2000, there were 1,428 people, 658 households, and 402 families residing in the CDP.

32.2% of all households were made up of individuals, and 14.1% had someone living alone who was 65 years of age or older.

This was the highest percentage of Egyptian Americans of any place in the country, although in raw numbers this is dwarfed by neighborhoods in Jersey City, New Jersey, and Queens, New York.

The most common ancestries in Espy are German (32%), Irish (13.9%), Dutch (11.2%), American (8.8%), British (7.6%), and Italian (6.8%).

[10] U.S. Route 11 forms the northern edge of the Espy CDP.