219214114ENSG00000077942ENSMUSG00000006369P23142Q08879NM_006487NM_001996NM_006485NM_006486NM_010180NM_001347088NP_001987NP_006476NP_006477NP_006478NP_001334017NP_034310FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.

[5][6][7] Fibulin-1 is a secreted glycoprotein that is found in association with extracellular matrix structures including fibronectin-containing fibers, elastin-containing fibers and basement membranes.

Fibulin-1 binds to a number of extracellular matrix constituents including fibronectin,[7] nidogen-1, and the proteoglycan, versican.

[6] The human fibulin-1 gene, FBLN1, encodes four splice variants designated fibulin-1A, B, C and D, which differ in their carboxy terminal regions.

In mouse, chicken and the nematode, C. elegans, only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.