Following the Second National Economic and Social Development Plan (1964–1966), the Thai government aimed to increase the number of doctors and nurses in order to meet the needs of the country.

In 2010, the faculty started construction on a second campus: the Chakri Naruebodindra Medical Institute (CNMI) (Thai: สถาบันการแพทย์จักรีนฤบดินทร์), located in Bang Phli district, Samut Prakan province.

On 3 December 2023, the faculty opened "Ramathibodi Health Space", an outpatient clinic located in Paradise Park mall.

This was part of the faculty's "decentralized medicine" concept, whereby patients could access tertiary care without having to travel to the main campus in central Bangkok.

There are 5 main hospital buildings which serve at least 5,000 out-patient visits per day and has more than a total of 1,000 beds for tertiary inpatient medical care.

The medical course aims to produce competent doctors with high professionalism, strong communication, teamwork, leadership and interpersonal skills.

For the 2018 academic year, a total of 180 undergraduate medical (RAMD) students were accepted into the course at the Faculty of Medicine Ramathibodi Hospital.