Feathery degeneration

In histopathology, feathery degeneration, formally feathery degeneration of hepatocytes, is a form of liver parenchymal cell (i.e. hepatocyte) death associated with cholestasis.

[1] Cells undergoing this form of cell death have a flocculant appearing cytoplasm,[2] and are larger than normal hepatocytes.

Feathery degeneration is somewhat similar in appearance to ballooning degeneration, which is due to other causes (e.g. alcohol, obesity); it also has cytoplasmic clearing and cell swelling.

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Feathery degeneration - large cells with pale flocculant cytoplasm (left-bottom and right-top). H&E stain .