State Road 580 (SR 580) is a major commercial and commuter route serving northern Pinellas and central Hillsborough County, Florida, The western terminus is an intersection with Broadway Street (U.S. Route 19 Alternate (US 19 Alt.

The historical eastern terminus is an intersection with US 301-SR 43 near Temple Terrace, two miles (3 km) to the east.

In Pinellas County (Dunedin, Safety Harbor, and Oldsmar) it is Skinner Boulevard, Main Street and Tampa Road.

A motorist continuing eastward on SR 580 in Hillsborough County drives on Tampa Road, Hillsborough Avenue (through Town 'n' Country), Dale Mabry Highway (between US 92-SR 600 and SR 597), and Busch Boulevard (which continues past the eastern SR 580 terminus as Bullard Parkway).

Most of the road runs halfway between SR 580 and the north shore of Safety Harbor.