Its western terminus is an intersection with US 17 (SR 35) in Zolfo Springs; the eastern terminus is an intersection with US 27-98 (SR 25-700) near DeSoto City.

The eastern continuation of SR 66 is eastbound US 98-SR 700 toward Okeechobee and West Palm Beach.

State Road 66 snakes through farmlands, woodlands, and wetlands in a sparsely populated region of southern Florida.

It is part of what's known as the Florida Cracker Trail.

[2] Media related to Florida State Road 66 at Wikimedia Commons