It is at the beginning of the western approach to Frankfurt Hauptbahnhof, which runs for about five kilometres and is up to 600 metres wide.

Freight and passenger trains are operated on the line by HFM Managementgesellschaft für Hafen und Markt mbH ("HFM Management Company for the Port and Market") and passenger trains are sometimes operated by the Historischen Eisenbahn Frankfurt ("Historic Railway, Frankfurt", CEF), using steam and diesel locomotives and railbuses.

The station is now in the centre of Griesheim, the largest district in the western part of Frankfurt, between the Main and the Mainzer Landstraße.

South of it is the historic heart of Griesheim, north of it are new estates built in the mid-20th century.

On the opposite side of the adjacent Autogenstraße (street) there are buildings from the period of the station's construction.