It is on the Main-Neckar Railway between Frankfurt and Heidelberg and is classified by Deutsche Bahn as a category 4 station.

Passenger trains initially ran between Louisa station and Offenbach to provide connections with services on the Main-Neckar Railway.

In 1997 lines S3 and S4 of the Rhine-Main S-Bahn were opened between Frankfurt Stresemannallee and Darmstadt Hauptbahnhof.

In December 2024 the S-Bahn network was changed and the route to Darmstadt is now served by line S6.

At the beginning of the 19th century the Frankfurt banker and diplomat Simon Moritz von Bethmann (1768–1828) acquired the land the parcel station was built on to create an English garden.