The station building was built in a relatively elaborate Renaissance Revival style to a design by Julius Eugen Ruhl.

As part of this project a connection was opened on 10 May 1884 from Bockenheim to the Homburg Railway, a connection that could not be built fifteen years earlier during the Homburg line's original construction because the various small states involved failed to come to an agreement.

In addition, a sweeping curve was built for the Main-Weser line's northern approach to the new Central Station.

Line 17 of the Frankfurt tramway, which opened in 2003, touches the southern end of the Westbahnhof (Nauheimer Straße and Kuhwaldstraße stops).

The M32 bus line runs from Westbahnhof via Frankfurt Nordend and Bornheim to Ostbahnhof.