The station was opened on 28 May 1978 and is named after a nearby medieval watchtower (the Galluswarte), which was named after the Galgenfeld ("gallows field", a place of execution).

It consists of two tracks facing a 96 cm-high central platform on the Homburg Railway and two passing tracks on the Main-Weser Railway.

There was formerly a junction at the station with a branch to the now closed main freight yard.

The station is elevated above the streets of Mainzer Landstraße and Frankenallee.

Intercity and regional trains run past on the Main Weser tracks, which have no platforms at Galluswarte.