In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides.

The nomenclature for members of the Gucy2 gene family is not consistent across species.

In many mammals, including mice and rats, the Gucy2d gene encodes a related protein – GC-D – that is specifically expressed in a subpopulation of olfactory sensory neurons.

[8] Mutations in this gene result in Leber's congenital amaurosis and cone-rod dystrophy-6 diseases.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.