[5][6] Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.

Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

GC-C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea.

Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin.

Guanylate cyclase 2C is the target of linaclotide and plecanatide, oligopeptide agonists used for the treatment of chronic constipation.