Epiphanes was named in honor of his father, his ancestors and the late Roman Client King Archelaus of Cilicia.
In 64, Epiphanes had married an Egyptian Greek woman from Alexandria called Claudia Capitolina.
In 70 Epiphanes was sent by his father with troops to command and assist the prince Titus to end the siege in Jerusalem.
In 72 Lucius Caesennius Paetus, the Roman Governor of Syria had sent letters addressed to Vespasian accusing Antiochus IV, Epiphanes and his brother Callinicus in planning to revolt against Rome and allying themselves with the King of Parthia.
The client Kings Aristobulus of Chalcis and Sohaemus of Emesa also supplied troops to Paetus.
There is a possibility that Epiphanes and Callinicus had a short-lived attempt to resist invasion, before they fled to Parthia.
Vespasian brought Epiphanes, with his family and Callinicus, peacefully back to Rome with an honourable Roman military escort.
In 72 Capitolina bore Epiphanes another child, a daughter named Julia Balbilla in Rome.
After the death of his father, Epiphanes and his family moved and finally settled in Athens Greece, where he died in 92.
His daughter Julia Balbilla became a prominent poet and became a travelling friend to the Roman Emperor Hadrian and his wife the Empress Vibia Sabina.