It borders Georgia to the north and Armenia to the south, as well as the economic regions of Shaki-Zagatala, Central Aran, Karabakh, East Zangezur, and Gazakh-Tovuz.

The region consists of the districts of Dashkasan, Goranboy, Goygol, Samukh, as well as the cities of Ganja and Naftalan.

[3] It has an area of 5,270 square kilometres (2,030 sq mi).

Its population was estimated to be at 611.3 thousand people in January 2021.

Its territory was part of the larger Ganja-Qazakh Economic Region before 2021.