It borders Iran to the south, as well as the economic regions of East Zangezur, Ganja-Dashkasan, Central Aran, and Mil-Mughan.

The region consists of the districts of Aghjabadi, Aghdam, Barda, Fuzuli, Khojaly, Khojavend, Shusha, and Tartar, as well as the city of Khankendi.

[3] It has an area of 8,990 square kilometres (3,470 sq mi).

Its population (including refugees and IDPs living outside the economic region in Azerbaijan) was estimated to be at 904.5 thousand people in January 2021.

Its territory mostly corresponded to the Upper Karabakh Economic Region before 2021, which included the districts of Aghdam, Tartar, Khojavend, Khojaly, Shusha, Jabrayil, Fuzuli and the city of Khankendi.