No section of SR 268 that is included as a part of the National Highway System.

The route heads north-northeast and curves to the northeast to enter Ambrose.

It heads northeast, crosses the Seventeen Mile River, and intersects SR 206 (Bowens Mill Road).

Northeast of Broxton, the route enters Jeff Davis County, and meets its eastern terminus, an intersection with SR 107 in Snipesville.

[6][7] By 1960, the road was paved from its western terminus to just northeast of the Coffee-Jeff Davis County line.