It runs southeast–northwest through portions of Ben Hill, Irwin, and Coffee counties.

The highway continues to the northwest until it reaches its northern terminus, an intersection with US 319/SR 107 east of Fitzgerald.

[1] SR 206 is not part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility and defense.

[2] State Route 206 Connector (SR 206 Connector) exists entirely within the southeastern part of Coffee County.

[3] SR 206 is not part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility and defense.