State Route 65 (SR 65) is a 17.0-mile-long (27.4 km) state highway located entirely in the southwestern part of Mitchell County in the southwestern part of the U.S. state of Georgia.

It connects the Hopeful and Pelham areas of the state.

It heads southeast and curves to the east toward Pelham.

The highway travels east-southeast through rural portions of the county and passes through the town of Branchville.

Once in Pelham, the route gradually bends to the east-southeast, until it meets its eastern terminus, an intersection with SR 93.