[citation needed] Between 1970 and 1973, he progressively abandoned research on particle physics and turned his attention principally to electroacoustics and digital sound.
He created a research center at the Naples University Physics Institute, where he developed numerous analog and digital systems controlled by a PDP11 computer for realtime generation and sound processing.
In 1974, he met Luciano Berio, who invited him to IRCAM in Paris to create an Electroacoustic Centre; this marked the beginning of a collaboration that continued until 2000.
At IRCAM, guided by the musical ideas of Pierre Boulez, di Giugno developed several prototypes of digital machines that in 1979 were consolidated in the "4X" system.
In 1988, Di Giugno returned to Italy to assume the direction of the IRIS research laboratory of the Bontempi-Farfisa group where, through 1999, he continued research in the field of large musical workstations, coordinating a Design Centre for the realization of specialized microprocessors handling digital sound signals.