She is the co-creator and co-host of the podcast This Might Get Weird (2018–present) alongside frequent collaborator Mamrie Hart and is the voice of Cindy Bear in the Max animated series Jellystone!

(2011–2012), played Idol on the Fine Brothers' web series MyMusic (2012–2013), and co-produced and starred in the feature films Camp Takota (2014), Electra Woman and Dyna Girl (2016) and Dirty 30 (2016).

To alleviate boredom and keep herself entertained, she began a daily vlog of her house sitting experience on her personal YouTube channel GracieHInABox.

In early 2008, Helbig narrated the short-lived animated web series, Bedtime Stories on My Damn Channel, which consisted of R-rated parodies of classic fairy tales.

In November 2013, the series was revived in a weekly format as My Damn Channel LIVE: Hangout, with Helbig making a few appearances via video chat from the Los Angeles studio.

On September 13, 2013, Helbig premiered her weekly web series Grace's Faces on beauty guru Bobbi Brown's newly created YouTube channel I love makeup.

[24] On July 1, 2014, Helbig and co-host Mamrie Hart premiered preview footage of their summer travel-themed web series #HeyUSA on the Astronauts Wanted YouTube channel.

Instead, Helbig introduced each episode and announced the location she chose for Hart and guest travel companions Kingsley, Tyler Oakley, Jenna Marbles, Colleen Ballinger, and Flula Borg.

[27] On March 31, 2016, in conjunction with AT&T Hello Lab, Helbig premiered a new series Writing With Grace on her YouTube channel, in which she instructed viewers to collaborate with her via Wattpad to co-write a novella called "Freak Week".

Helbig, along with other fellow YouTube personalities, held a live reading of the completed novella at VidCon on June 24, 2016.

[29] Starting on March 5, 2018, Helbig and Mamrie Hart began hosting a new YouTube show together called This Might Get...[30] on a dedicated channel of the same name.

Each episode had a different title, with the premiere being called "This Might Get Started", and focuses on a different topic, meme, or pop culture event.

In July 2013, in the last three episodes of Season 2 Part 2 of the hit web series The Most Popular Girls in School, Helbig voiced Jeannie Halverstad, the abrasive show host of Cheer Nationals.

In May and June 2014, Helbig appeared as Anna in two episodes of the second season of the musical web series Side Effects on the AwesomenessTV YouTube channel.

[34] On February 26, 2015, it was announced via various media outlets that Helbig would be co-starring with Hannah Hart in a reboot of the 1970s Sid and Marty Krofft live action science fiction television series Electra Woman and Dyna Girl.

[35][36] On August 6, 2015, Helbig was featured in a series of online commercials for Marriott Hotels & Resorts for the company's "It Pays to Book Direct" ad campaign.

[38] Beginning September 21, 2019, Helbig appeared as animal expert Annalise in the eight episode Comedy Central Facebook Watch web series Beast to Beauty.

[39] She voices Cindy Bear, Yappee, Taffy and Granny Sweet in the HBO Max animated series Jellystone!

In preparation for the show, Helbig was interviewed live via satellite on multiple local television news broadcasts across the United States on March 27, 2015.

[47] Helbig appears in Alex Winter's Smosh: The Movie, starring Anthony Padilla and Ian Hecox, alongside fellow YouTubers Jenna Marbles, Markiplier, Harley Morenstein and others.

[48][49] Helbig co-starred with Hannah Hart in a reboot of the 1970s Sid and Marty Krofft live action science fiction television series Electra Woman and Dyna Girl.

New full-length episodes are made available each Monday on SoundCloud and iTunes, with video footage featured on Helbig's YouTube channel.

On February 11, 2021, Rooster Teeth announced that Helbig and Hart would host a supplemental 10-episode podcast under the This Might Get Weird umbrella beginning March 5, 2021, entitled How Ya Been?, in which the two interview other veteran YouTube personalities.

[59] On March 29, 2020, Helbig premiered this audio-video podcast alongside co-host Elliott Morgan, in which they review reality television.

In addition to her web and television content, Helbig has performed live on stage in various formats throughout the United States, Canada, England, Ireland and Australia, including the following: In 2011, Helbig co-hosted the monthly live late night stage show Morning Show with Jacob "Hobart" Brown.

[60][61] On January 15, 2013, Helbig participated on stage as part of "An Evening of Awesome" with John and Hank Green, Neil Gaiman, Hannah Hart, Ashley Clements and Daniel Vincent Gordh.

They encouraged people to film and document the show and incorporated the use of social media by using internet comments and Twitter mentions in crowd games.

[63] On March 15, 2014, Helbig and Mamrie Hart performed a one-off live comedy show, This Might Get Weird, Y'all in Boston.

On July 25, 2014, Helbig performed along with comedians Steve Agee and Brian Posehn at San Diego's Comic Con as a part of Comedy Central presents "@midnight".

[68] On September 26, 2015, Helbig recorded an episode of her Not Too Deep podcast (with guest Harley Morenstein) in front of a live audience in Toronto as part of the JFL42 comedy festival.