Grammichele (Sicilian: Grammicheli, Greek: Echetle (meaning "plowshare"); Latin: Echetla, Ochula; Medieval: Occhiolà) is a town and comune in the Metropolitan City of Catania in Sicily, southern Italy.

Occhiolà, on account of the similarity of name, is generally identified with Echetla, a frontier city between Syracusan and Carthaginian territory in the time of Hiero II, which appears to have been originally a Sicel city in which Greek civilization prevailed from the 5th century onwards.

In the center of the hexagon is the Piazza Carlo Maria Carafa, faced by the Chiesa Madre (Mother Church), San Michele Arcangelo, and the Palazzo Communale (City Hall).

The town of Avola, destroyed by the same earthquake, was also relocated and rebuilt along a hexagonal layout.

To the east of Grammichele a cave shrine of Demeter, with fine votive terracottas, was discovered.