Grindstone Creek is a stream in Clinton, DeKalb and Daviess counties in the U.S. state of Missouri.
The stream headwaters are in northern Clinton County south of the community of Osborn at 39°43′50″N 94°22′01″W / 39.73056°N 94.36694°W / 39.73056; -94.36694.
The stream flows northeast through southeastern DeKalb County past the community of Fordham and passing under Missouri Route 6 1.5 miles east of Weatherby.
It enters Daviess County approximately three miles northeast of Weatherby and flows north crossing under Missouri Route E one half mile west of Santa Rosa.
This article related to a river in Missouri is a stub.