It connects Tokyo's Inner Circular Route in central Tokyo to Haneda International Airport, one of the Tokyo area's two international airports, as well as the Yokohane Route, which leads to Kawasaki and Yokohama in Kanagawa Prefecture.

The first section of the Haneda Route between Hamazakibashi and Shibaura was opened to traffic on 20 December 1962.

The second section to be completed between Shibaura and Suzugamori was finished on 21 December 1963.

The fourth and final section between Haneda-nishi and Haneda was opened on 21 December 1966.

[1] Route C1 Inner Loop to Ginza and Hakozaki entrance/exit area connection