From this eastern terminus, it travels west through central Yokohama as an elevated highway over the Nakamura River.

Continuing west the expressway enters Minami-ku, where it has some junctions with various municipal and prefecture roads.

At Hanaoki, the Kariba Route leaves the Nakamura River curving to the northwest, eventually entering Hodogaya-ku.

[2] The first section of the Kariba Route was opened to traffic on 2 February 1984 between the interchanges at Shin-yamashita and Yokohama-kōen.

Next, it was extended west to Kariba Junction, the expressway's western terminus, on 20 March 1990.