It connects the Inner Circular Route at Kandabashi Junction in Chiyoda Ward to the Tokyo Expressway at Nishi-ginza Junction in Chūō Ward.

It primarily serves Tokyo Station and its surroundings.

All large truck traffic is banned on this route.

[1] The main part of the expressway between Kandabashi and Nishi-Ginza was completed in 1973.

A short section of expressway between the Inner Circular Route and the southern end of the Tokyo Expressway is designated as a section of the Yaesu Route.