It primarily connects the central part of Saitama to the Ōmiya Route and, by extension, the Ikebukuro Route which connects it to the rest of the Shuto Expressway system and central Tokyo.

[1] There are plans to extend the Saitama Shintoshin Route to the east from its current terminus at Saitama-minuma to a junction with the Tōhoku Expressway.

[2] The first section of the Saitama Shintoshin Route between the expressway's western terminus at Yono Junction and Shintoshin-nishi, was opened to traffic on 17 April 2000.

The next section between Shintoshin-nishi and Shintoshin was opened on 26 May 2004 after delays caused by unstable soil made construction difficult.

The final section of the expressway between Shintoshin and the eastern terminus at Saitama-minuma was opened on 4 August 2006.