The route is a 10.6-kilometer (6.6 mi) long radial highway running northeast from Katsushika in Tokyo to the city of Misato in Saitama Prefecture.

Alongside the Mukojima Route, it connects Tokyo's Inner Circular Route in central Tokyo to the Jōban Expressway, which connects the Kantō region to the Tōhoku region.

From this southern terminus, it travels northeast out of Katsushika, crossing in to Adachi, Tokyo.

In Saitama the expressway passes through the city of Yashio before entering the city of Misato where it meets its northern terminus at Misato Junction where it intersects the Tokyo Gaikan Expressway.

[1] The speed limit is set at 60 km/h between Kosuge Junction and the interchange at Kahei.