The station is served by Amtrak's Crescent passenger train, and is the last regular stop before its southern terminus in New Orleans.

[3] Designed by architect Frank Pierce Milburn,[4] and built in 1910 for the New Orleans and Northeastern Railroad, the depot is a 1+1⁄2-story brick structure of Italian Renaissance Revival architectural style.

In 2000, the City of Hattiesburg acquired the depot plus approximately 3 acres (1.2 hectares), surrounding the structure, from Norfolk Southern Railway and began extensive repairs and restoration to convert the facility into an intermodal transportation center for bus and taxi service, in addition to the railway.

[7] Besides serving as an intermodal transportation center for the City of Hattiesburg, the depot's Grand Hall is used for art exhibits, social functions, and private events.

[7] The Grand Hall is no longer used for arrivals and departures by rail; a separate waiting area, in the depot, accommodates Amtrak passengers.