The station is served by Amtrak's Crescent passenger train.

The station house was built in 2008 as a replacement for an open covered shelter.

Since the suspension of the Sunset Limited east of New Orleans in 2005, Picayune has been the only Amtrak station on the Mississippi Gulf Coast.

Media related to Picayune (Amtrak station) at Wikimedia Commons

This Mississippi train station-related article is a stub.