Amtrak service to Biloxi began with the Gulf Coast Limited, which operated between 1984 and 1985.

[2][3] The stop was reactivated on March 31, 1993 in service on the Sunset Limited.

[4] Damage to the rail line resulting from Hurricane Katrina in 2005 caused Amtrak to suspend service east of New Orleans,[1] including at Biloxi.

Into the late 1960s, at another Biloxi station, the Louisville & Nashville operated the daily trains, Gulf Wind (New Orleans–Jacksonville), Pan-American (New Orleans–Cincinnati) and Humming Bird (New Orleans–Cincinnati), as well as an additional unnamed day train (New Orleans–Jacksonville).

[5] Additionally, the Southern Railway operated the Crescent and Piedmont Limited (both: New Orleans–New York) through that station.