The District extends from I-70 on the west and the I-270 bridge on the east, covering 78 square miles, an area larger than the City of St. Louis.

[4] The District covers a large portion of north St. Louis County, Missouri, including all of Black Jack and Spanish Lake.

Additionally it includes portions of: Bellefontaine Neighbors, Berkeley, Bridgeton, Dellwood, Ferguson, Florissant, Glasgow Village, Hazelwood, and Old Jamestown.

[11][12] In 2022, radioactive materials including lead-210, polonium, and radium, were found at the district's Jana Elementary School.

It arose from dumps of munitions during World War II at St. Louis Lambert International Airport, and had flowed from there in Cold Water Creek to the school which lies in its floodplain.