Highbury Avenue is an arterial road and municipal expressway located in the Canadian province of Ontario.

In addition to serving as a primary north–south thoroughfare in eastern London – through which part of it is a limited-access freeway – the road also provides access to Highway 401 and continues south to St. Thomas.

It was extended south of the river to Highway 401 as a four-lane freeway in 1963, which the City of London named the Wenige Expressway in 1965.

Highbury Avenue is a 45.6 kilometres (28.3 mi) road that travels north from St. Thomas, through London, to Highway 7, east of Elginfield.

[2][5] The southern terminus of Highbury Avenue is an intersection with South Edgeware Road, just north of Highway 3 and the eastern end of the St. Thomas Expressway.

It travels in a straight line north as a two lane road through an industrial park on the outskirts of St. Thomas and crosses the Ontario Southland Railway tracks.

[6][7] Dipping into the Kettle Creek valley, Highbury Avenue passes the trailhead of the Dan Patterson Conservation Area at Mapleton Line.

[8] Highbury Avenue crosses from Central Elgin into the city of London at the intersection of Webber Bourne and Thompson Line, although the surroundings remain agricultural.

It travels between farm fields for the next 8 km (5 mi), with the LEED Certified London Southeast Pumping Station and Reservoir near the ghost village of Hubrey breaking the monotony.

It curves back northward parallel to and east of high-voltage transmission lines before encountering an interchange with Bradley Avenue.

[6][7] North of the Thames River, what would eventually become Highbury Avenue was first laid out as a concession road in the original survey of London Township.

In February 1958, a new four-lane overpass of the CPR north of Dundas Street was opened, replacing an old bridge that had existed since at least 1915.

[1][25] Despite objections from the DHO, which preferred the readability of a number on signage for safety reasons, London ordered signs erected with the name in May 1965.

[26] However, the DHO prevailed and these signs were only installed along a 330 metres (1,080 ft) section between Power Street and Hamilton Road.

[27] In October 1964, potential route locations for several controlled-access highways around London were revealed to Middlesex, Elgin and Oxford county officials.

[29] The DHO-commissioned London Area Highway Planning Study, published in July 1966, examined traffic patterns and determined ideal travel lines and redundant routes.

Following completion, a CA$20 million contract is set to begin in late 2022 to rebuild the route south of the bridge to Highway 401.