Homestead is a town in Florence County, Wisconsin, United States.

As of the census[2] of 2000, there were 378 people, 158 households, and 109 families residing in the town.

There were 351 housing units at an average density of 6.5 per square mile (2.5/km2).

The racial makeup of the town was 98.68% White, 0.26% Native American, 0.26% Asian, 0.26% Pacific Islander, and 0.53% from two or more races.

26.6% of all households were made up of individuals, and 9.5% had someone living alone who was 65 years of age or older.