Physiologically, homoarginine increases nitric oxide (NO) supply and betters endothelial functions in the body, with a particular correlation and effect towards cardiovascular outcome and mortality.

In its inhibition, is also often found in occurrences with the lungs, cervix, testis and is an inhibitor of bone and liver-specific alkaline phosphatase enzymes.

Homoarginine is used clinical studies, often with rats, to explore its effects on cardiovascular health by acting as an inhibitor for organ-specific reactions as well as a stimulator in some cases.

A recent study was done on the topic of homoarginine related to heart failure and sudden cardiac death in haemodialysis patients.

The study calculations showed that the risk of sudden cardiac death had a threefold increase in the presence of per unit decrease of homoarginine.

This explained the strong association of congestive heart failure and left ventricular hypertrophy with low homoarginine levels.