[2] Initial conquest of Honduras proved to be difficult as the native tribes in the territory overwhelmingly resisted the Spanish invasion.

Honduras declared its own independence from Spain on 15 September 1821 and chose to join the Mexican Empire under Emperor Agustín de Iturbide.

Honduras, along with Costa Rica, El Salvador, Guatemala and Nicaragua formed the Federal Republic of Central America.

As a result of the coup d'état, Spain expelled the Honduran ambassador in Madrid who supported the removal of President Zelaya from power.

[9] Spanish prime minister Pedro Sánchez visited Honduras in August 2022, meeting with Honduran president Xiomara Castro.

[10] They vowed to deepen the economic and trade relations, also signing a memorandum of understanding pertaining the strengthening of cooperation in the healthcare sector.