[2][failed verification] Lakeshore proceeds along Burlington Beach as a three-lane road (the third being a centre turning lane), passing the Joseph Brant Hospital.

East of downtown, Lakeshore enters a long, predominantly wealthy, leafy residential stretch consisting of a mix of lakefront mansions, parklands, and a few apartment buildings, a setting which characterizes the road through most of Halton Region.

After passing through more residential areas, it travels through Kerr Village, crosses the Sixteen Mile Creek and comes into downtown Oakville.

Lakeshore ends at Mississauga's eastern boundary at the Etobicoke Creek beside Marie Curtis Park, where it continues as Toronto's Lake Shore Boulevard.

Lakeshore Road originated as a Native trail running along the shore of Lake Ontario east from the vicinity of present-day downtown Burlington as far as today's Fourth Line in Oakville.

The remainder of the route west to Port Credit was abandoned in 1935, due to competition from automobiles and intercity bus service.

[11] But street railways would return to Lake Shore Road west of Toronto, albeit only temporarily: During World War II.

As a result of the new highway, Lake Shore was relieved of its heavy traffic, and was able to retain its narrow width for most of its length, which it still has today.

The portion in what became Metropolitan Toronto was rechristened as Lake Shore Boulevard during this time period, officially truncating it to the Etobicoke Creek at what is today's Mississauga-Toronto city limits.