Hypolipoproteinemia, hypolipidemia, or hypolipidaemia (British English) is a form of dyslipidemia that is defined by abnormally lowered levels of any or all lipids and/or lipoproteins in the blood.

Causes of hypolipidemia include:[citation needed] It can be diagnosed via blood study that identifies fat particles.

The patient must fast overnight to prevent interference from fat in the blood due to food intake.

[2] In humans with genetic loss-of-function variants in one copy of the ANGPTL3 gene, the serum LDL-C levels are reduced.

[3] Hooft disease is a rare condition evidenced by low blood lipid level, red rash and mental and physical retardation.