Eruptive xanthomas are 2–5 mm papules, often with a red ring around them, that occur in clusters on the skin of the trunk, buttocks and extremities.

[2] Familial dysbetalipoproteinemia causes larger, tuberous xanthomas; these are red or orange and occur on the elbows and knees.

The symptoms are similar to pancreatitis secondary to other causes, although the presence of xanthomas or risk factors for hypertriglyceridemia may offer clues.

[9] In 2016, the United States Preventive Services Task Force concluded that testing the general population under the age of 40 without symptoms is of unclear benefit.

[12][1][13][14] This may include dietary changes such as restriction of fat and carbohydrates (specifically fructose[13][15] and sugar-sweetened beverages[1]) and increased consumption of omega-3 fatty acids from algae, nuts, and seeds.

[16][17] The decision to treat hypertriglyceridemia with medication depends on the levels and on the presence of other risk factors for cardiovascular disease.

Very high levels that would increase the risk of pancreatitis is treated with a drug from the fibrate class.