[5] Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors.

Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities.

Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth.

Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.