Icodextrin (INN, USAN) is a colloid osmotic agent, derived from maltodextrin,[1] used in form of an aqueous solution for peritoneal dialysis under the trade name Extraneal,[2] and after gynecological laparoscopic surgery for the reduction of post-surgical adhesions (fibrous bands that form between tissues and organs) under the trade name Adept.

[3] The osmotic activity of icodextrin keeps the solution inside the peritoneum for three to four days, separating tissues and thus reducing adhesion between them when fibrin is formed after a surgery.

[2][3] Icodextrin is contraindicated in patients with cornstarch allergy, maltose or isomaltose intolerance, glycogen storage disease, or severe lactic acidosis.

[5] Adverse effects include peritonitis, respiratory infection, hypertension (high blood pressure), rashes, and headache.

Of these side effects, only hypertension and rashes occurred significantly more often than under glucose solution; the other events seem to be related to peritoneal dialysis in general.