Immaculate Conception Cathedral is a historic church at 1218 East Jefferson Street in Brownsville, Texas, United States.

It was built in 1856 and added to the National Register of Historic Places in 1980 as Immaculate Conception Church.

[2] The first Catholic bishop to reside at Immaculate Conception was Dominic Manucy who was the Vicariate Apostolic of Brownsville.

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