Impalefection

Plasmid DNA containing the gene, and intended for intracellular delivery, is attached to the nanostructure surface.

As one of the types of transfection, the term is derived from two words – impalement and infection.

One of the features of impalefection is spatially resolved gene delivery that holds potential for such tissue engineering approaches in wound healing as gene activated matrix technology.

[2] Though impalefection is an efficient approach in vitro, it has not yet been effectively used in vivo on live organisms and tissues.

[3] Vertically aligned carbon nanofiber arrays prepared by photolithography and plasma enhanced chemical vapor deposition are one of the suitable types of material.

An SEM image of epitaxial nanowire heterostructures grown from catalytic gold nanoparticles.