Twenty-four years later, Purdue University permanently established the Purdue University Center at a separate location in downtown Fort Wayne to provide a site for students to begin their undergraduate studies prior to transferring to the West Lafayette main campus to complete their degree.

[1] The Main Academic Campus, bounded by East Coliseum Boulevard (Indiana State Road 930) to the south, Crescent Avenue to the east, St. Joseph River to the west, and Canterbury Green Apartment complex and golf course to the north includes the majority of academic and administrative buildings and parking.

This area of the campus was acquired in 2007 after the Fort Wayne State Developmental Center's closure,[4] with the land donated between IPFW and Ivy Tech Community College of Indiana.

The Plex indoor soccer facility, Hefner Soccer Complex, Holiday Inn hotel, and Steel Dynamics Keith E. Busse Alumni Center are located on this portion of the campus, connected to the main academic campus via the pedestrian-only Ron Venderly Family Bridge.

[5] IU Fort Wayne offers degree programs in dentistry, nursing, medical imaging, medicine, and social work.