Abnormal levels of integrin beta-1D have been found in limb girdle muscular dystrophy and polyneuropathy.

All integrins, alpha and beta forms, have large extracellular and short intracellular domains.

[7] Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells.

[14] The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion.

[20] In patients with limb girdle muscular dystrophy, type 2C, beta-1D integrin has been shown to be severely reduced in skeletal muscle biopsies, coordinate with a reduction in alpha 7B-integrin and filamin 2.