The easternmost auxiliary route of I-10, it is also known as the Reubin O'Donovan Askew Parkway in honor of the former governor of Florida who originated in Pensacola.

I-110 is elevated on separate viaducts for northbound and southbound lanes throughout this initial 2.4-mile (3.9 km) span through downtown Pensacola.

Both northbound ramps of exit 4 are located in the southeast quadrant of the intersection and directly connect to Davis Highway (SR 291).

In the 1990s, there was official discussion of extending I-110 north to US 90 Alternate (Nine Mile Road) and possibly as far as I-65 in southwestern Alabama.

Reconstruction of the freeway included access to and from Airport Boulevard via a modification of the existing Brent Lane interchange.