Iotated E has no equivalent in the Glagolitic alphabet, and probably originated as a ligature of ⟨і⟩ and ⟨е⟩ to represent the sounds [je] or [jɛ].

Iotated E is found in some of the very oldest examples of Cyrillic writing, such as the tenth-century Mostich inscription or the Codex Suprasliensis, whereas in others, such as the Enina Apostle or Undol'skij Fragments, it is not present at all.

Among the Eastern Slavs ⟨ѥ⟩ fell into disuse after the end of the fourteenth century, and it is not therefore represented in printed books from this area, or in modern Church Slavonic.

In the South, however, it survived, and was used in the first Serbian printed book, the Octoechos (Oktoih prvoglasnik) of 1474, and appears in the Serbian abecedarium printed in Venice in 1597;[1] its position in the alphabet in this book is between ⟨ю⟩ and ⟨ѯ⟩.

It continued to be used in both manuscript and printed material throughout the sixteenth and seventeenth centuries, but it no longer appears in the alphabet in M. Karaman's abecedarium of 1753.