[4] A remix version featuring Demi Lovato, was released on October 16, 2015 (same day as her fifth studio album Confident) and peaked at No.

[5] The song is the first track on Fall Out Boy's sixth studio album American Beauty/American Psycho, and it runs a length of three minutes and twenty seconds.

Bassist Pete Wentz compared the mood of the song to a scene in the biopic Sid and Nancy.

[7] "When I think of "Irresistible", it brings this image to my head, whether it's fictional or real, of Sid and Nancy in an alley, garbage raining down on them in an eternal spiral of romance and poison.

The day of the digital release, it reached the top of the iTunes download chart,[9] which helped it debut and peak at No.

[10] The song was used by WWE for their Extreme Rules PPV event and it is also featured in the promotional spots for the miniseries Heroes Reborn.

"Irresistible" has received positive reviews from music critics, with many commenting on the anthemic nature of the song.

MTV wrote positively of the song, calling it a "frantic twist of desperation, confidence and sadism with a chugging guitar, anthemic trombones and a shout-it-at-the-top-of-your-lungs chorus.

The video is directed by Wayne Isham and features cameo appearances by NSYNC members Chris Kirkpatrick and Joey Fatone.